Cristina Cariulo

This paper develops and validates recombinant monoclonal antibodies that selectively detect specific huntingtin neoepitopes, addressing variability in existing antibodies and enabling new research into huntingtin fragment cleavage mechanisms.

The paper develops an ultrasensitive immunoassay to detect S421 phosphorylation of huntingtin in HD models and nonhuman primate CSF, linking it to disease progression and identifying PRKACA as a kinase involved.

The paper shows IKBKB reduces mutant huntingtin aggregation by phosphorylating S13 via a non-canonical IKK pathway.

This study shows that striatal cholesterol infusion prevents cognitive decline and improves motor function in HD mice, with dose-dependent benefits and synaptic recovery.