AR-V7 condensates drive androgen-independent transcription in castration resistant prostate cancer
Shabnam Massah, Nicholas C. Pinette, Jane Foo, Sumanjit Datta, Maria Guo, Robert H. Bell, Anne M. Haegert, Emirhan Tekoglu, Mailyn Terrado, Stanislav V. Volik, Stéphane Le Bihan, Jennifer M. Bui, Nathan A. Lack, Martin Edwin Gleave, Suhn K. Rhie, , Nada Lallous
This study shows AR-V7 forms condensates independently of androgens and AR-FL in CRPC, driving oncogenic transcription through both condensate-dependent and -independent mechanisms.
bioRxiv · Jan 8, 2025 · PreprintCancer Biology