Author

Nicholas Hagspiel

University of Virginia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:proteomics· 1

Frequent Co-Authors

Farha NaziD· 2 shared William A. PetriiD· 2 shared Audrey C. BrowniD· 1 shared Brandon A. ThompsoniD· 1 shared Christopher B. FoxiD· 1 shared Claire FlemingiD· 1 shared David Tyus· 1 shared Feifan Xu· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersImmunology

Farha NazORCID

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2 papers

Recent·Most cited

IL-33 protects from recurrent C. difficile infection by restoration of humoral immunity

Farha Naz, Md Jashim Uddin, Nicholas Hagspiel, Mary K. Young, David Tyus, Rachel Boone, Audrey C. Brown, Girija Ramakrishnan, Isaura Rigo, Claire Fleming, Gregory R. Madden, William A. Petri

The paper shows IL-33 prevents recurrent C. difficile infection by restoring anti-TcdB antibody production through ILC2-TFH cell interactions.

Journal of Clinical Investigation · Mar 6, 2025Peer-reviewedImmunology

Enhanced immunogenicity of a Clostridioides difficile TcdB vaccine adjuvanted with a synthetic dual-TLR ligand adjuvant.

Farha Naz, Nicholas Hagspiel, Feifan Xu, Brandon A. Thompson, G. Brett Moreau, Mary Young, Joel F. Herbein, Christopher B. Fox, William A. Petri, Mayuresh M. Abhyankar

This paper evaluates a TcdB vaccine adjuvanted with a dual-TLR ligand liposome, showing complete protection against lethal CDI in mice and superior antibody and memory B cell responses compared to alum.

npj Vaccines · Feb 18, 2025Peer-reviewedImmunology