Integrin-identity shapes and mechanotemporally encodes the fibroblast transcriptome
Upnishad Sharma, Michele M. Nava, Luca F. Witte, Nicholas Luginbuehl, Huanding Ji, Michal J. Okoniewski, Rebecca Kottke, Barbara Treutlein, Reinhard Faessler, Daniel J. Müller
This study shows integrin-identity shapes fibroblast transcriptomes under mechanical confinement, with distinct gene clusters and states depending on integrin class and confinement duration.
bioRxiv · Jun 19, 2026 · PreprintCell Biology