Upnishad Sharma

This study shows fibroblasts use two distinct adhesion strengthening modes, slow and fast, in response to fibronectin stiffness, with fast mode dependent on myosin II and signaling hub components.

This study shows integrin-identity shapes fibroblast transcriptomes under mechanical confinement, with distinct gene clusters and states depending on integrin class and confinement duration.

This study reveals how V-class integrins rapidly sense RGD motifs and reprogram cell adhesion and mechanics through distinct mechanotransduction pathways.