Daniel J. Müller

This study shows fibroblasts use two distinct adhesion strengthening modes, slow and fast, in response to fibronectin stiffness, with fast mode dependent on myosin II and signaling hub components.

This study shows integrin-identity shapes fibroblast transcriptomes under mechanical confinement, with distinct gene clusters and states depending on integrin class and confinement duration.

This study proposes a physical model of the nucleus that explains its mechanical behavior under deformation, highlighting the role of the envelope and chromatin in nuclear mechanics.

This study shows that tumor cell viscosity affects their ability to circulate and extravasate, influencing metastasis.

This study reveals how V-class integrins rapidly sense RGD motifs and reprogram cell adhesion and mechanics through distinct mechanotransduction pathways.

The paper integrates single-cell transcriptomes and spatial transcriptomics to identify therapeutic targets in pancreatic cancer by analyzing cell states and ligand-receptor interactions in tumoroids.

This study shows membrane tension drives NINJ1 filament opening, causing cell lysis, and explains why NINJ2 fails to form lesions.