Dye-cycling DNA origami rotors for long-term tracking of transcription at base-pair resolution
Amanda L. Wacker, Ryan J. Fantasia, Brian Tenner, Boyu Liu, Jerry D. Wu, Nicholas Monell, Pallav Kosuri
This paper introduces dcORBIT, a method that extends DNA rotation tracking during transcription to over 10 minutes at 20 Hz with single base-pair precision.
Cell Reports Methods · Aug 13, 2026Peer-reviewedBiophysics