Author

Brian Tenner

Salk Institute for Biological StudiesORCID 0000-0002-7864-5285Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Cell Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Assay:fluorescence / live-cell microscopy· 2 Organism:E. coli· 1 Organism:mouse· 1 Approach:statistical model· 1 Research Focus:transcription & RNA processing· 1

Frequent Co-Authors

Jin ZhangiD· 2 shared Amanda L. WackeriD· 1 shared Ambhighainath GanesaniD· 1 shared Andre LevchenkoiD· 1 shared Ben GrossiD· 1 shared Boyu LiuiD· 1 shared Ha Neul LeeiD· 1 shared Jerry D. Wu· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersCell Biology

Jin ZhangORCID

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3 papers

Recent·Most cited

Dye-cycling DNA origami rotors for long-term tracking of transcription at base-pair resolution

Amanda L. Wacker, Ryan J. Fantasia, Brian Tenner, Boyu Liu, Jerry D. Wu, Nicholas Monell, Pallav Kosuri

This paper introduces dcORBIT, a method that extends DNA rotation tracking during transcription to over 10 minutes at 20 Hz with single base-pair precision.

Cell Reports Methods · Aug 13, 2026Peer-reviewedBiophysics

Oscillatory signal decoding within the ERK cascade

Ambhighainath Ganesan, Ha Neul Lee, Brian Tenner, Sohum Mehta, Andre Levchenko, Jin Zhang

The paper investigates how Ca2+ oscillations are decoded by the ERK cascade in pancreatic β-cells using fluorescent biosensors and reveals sequential signal processing along the pathway.

bioRxiv · Jul 24, 2025 · PreprintCell Biology

Spatiotemporal orchestration of calcium-cAMP oscillations on AKAP/AC nanodomains is governed by an incoherent feedforward loop

Lingxia Qiao, Michael Getz, Ben Gross, Brian Tenner, Jin Zhang, Padmini Rangamani

The paper develops computational models of the Ca2+/cAMP pathway and AKAP/AC nanodomains, predicting incoherent feedforward loop behavior in Ca2+/cAMP oscillations.

bioRxiv · Jan 29, 2024 · PreprintSystems Biology