The mechanism of biofilm degradation by a detachable tailspike of gene transfer agents
Pavol Bárdy, Phuong M. Nguyen, Yan Liu, Matthew W. Craske, Nicholas Read, Rebecca Mason Davies, J.P. Turkenburg, Sam Hart, Alfred A. Antson, Paul C. M. Fogg
This study identifies TspA, a biofilm-degrading enzyme from Rhodobacter capsulatus GTA, which enhances gene transfer by clearing biofilms and navigating the extracellular matrix.
bioRxiv · Jul 20, 2026 · PreprintBiochemistry