Shared molecular regulation of quiescence in neural and glioma stem cells reveals therapeutic vulnerabilities.
Chandra Choudhury, Matthew Singleton, Stephanie Brauer, Dana Friess, Jessica A. Hart, Niclas Skarne, Karthik Pullela, Likai Mao, Bryan W. Day, Lachlan Harris
This study identifies shared molecular mechanisms regulating quiescence in neural and glioma stem cells and suggests TGF-β inhibition as a potential therapeutic strategy.
bioRxiv · Jan 22, 2025 · PreprintCancer Biology