Lachlan Harris

This study identifies PRDM9 as a factor promoting survival of drug-tolerant persister cells in glioblastoma through metabolic rewiring and cholesterol biosynthesis.

The paper identifies sequential transcription factor programs that govern the activation of quiescent hippocampal stem cells through single-cell transcriptomic analysis in mice.

This study identifies shared molecular mechanisms regulating quiescence in neural and glioma stem cells and suggests TGF-β inhibition as a potential therapeutic strategy.

This study investigates the role of PRC2 in mouse cortical development, finding that homozygous mutations lead to structural and neuronal dysregulation, while heterozygous mutations show distinct effects.

This study uses spatial transcriptomics to analyze a DIPG-infiltrated brainstem, identifying invasion markers and ligand-receptor pairs involved in tumour-TME crosstalk.

This study shows that Wnt/beta-catenin signaling is not required for adult hippocampal NSC homeostasis, despite their responsiveness to the signal.

The paper shows that hippocampal stem cells in mice undergo progressive behavioral changes that reduce depletion and ensure lifelong neurogenesis.

The paper identifies altered nucleocytoplasmic partitioning and nuclear accumulation of polyadenylated transcripts as conserved features of quiescence in neural stem cells.