Structure and dynamics determine G protein coupling specificity at a class A GPCR
Marina Casiraghi, Haoqing Wang, Patrick C. Brennan, Chris H. Habrian, Harald Hübner, Maximilian F. Schmidt, Luis Maul, Biswaranjan Pani, Sherif M. F. M. Bahriz, Bing Ying Xu, Nico Staffen, Tufa E. Assafa, Bohan Chen, Elizabeth White, Roger K. Sunahara, , Brian K. Kobilka
This study identifies structural features determining G protein coupling specificity at a class A GPCR using a Gi-biased agonist.
Science Advances · Mar 19, 2025Peer-reviewedMolecular Biology