Author
Duke Medical CenterORCID 0000-0003-4811-4632Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Patrick J. Brennan, Alexander M. Garces, Julian D. Grosskopf…·Michael T. Lerch
This study reveals the unliganded active state of the β2-adrenergic receptor using pressure-resolved DEER and ProGuide modeling, showing pressure-dependent conformational changes and allosteric coupling.
Preston J. Anderson, Peng Xiao, Ya-Ni Zhong…·Sudarshan Rajagopal
This study shows β-arrestin condensates regulate GPCR function through liquid-liquid phase separation, influencing internalization and signaling.
Natalia Pakharukova, Brittany N. Thomas, Harsh Bansia…·Robert J. Lefkowitz
The paper reveals how beta-arrestin 1 activates Src kinase via two distinct SH3 domain interactions, using cryo-EM to show structural mechanisms of beta-arrestin-mediated signaling.
Marina Casiraghi, Haoqing Wang, Patrick C. Brennan…·Brian K. Kobilka
This study identifies structural features determining G protein coupling specificity at a class A GPCR using a Gi-biased agonist.