Ehud Y. Isacoff

Reversible Antagonism of Dopamine D1 Receptor using a Photoswitchable Remotely Tethered Ligand

The paper develops a photoswitchable antagonist for the dopamine D1 receptor to enable precise temporal and spatial control of receptor activity in the brain.

Deficiency in transmitter release triggers homeostatic transcriptional changes that increase presynaptic excitability

The paper shows that weakening synaptic transmission in Drosophila larvae leads to transcriptional changes that increase presynaptic excitability.

Structure and dynamics determine G protein coupling specificity at a class A GPCR

This study identifies structural features determining G protein coupling specificity at a class A GPCR using a Gi-biased agonist.

Synapse-to-synapse plasticity variability balanced to generate input-wide constancy of transmitter release

The paper shows that synaptic release probability varies across synapses but remains constant overall due to balanced facilitation and depression.

Circuit firing homeostasis following synaptic perturbation ensures robust behavior

The paper shows that synaptic weakening in Drosophila motor neurons is compensated by increased firing and reduced inhibition, maintaining locomotion.

Restoration of high-sensitivity patterned vision in motion with an engineered light-gated G protein-coupled receptor

This paper demonstrates a chemical-optogenetic approach that restores high-sensitivity motion vision in an IRD mouse model using a multi-branched photoswitch.

Multiplexed temporally focused light shaping for high-resolutionmulti-cell targeting

The paper introduces a method for high-resolution multi-cell optogenetic targeting using temporally focused light shaping in Drosophila and zebrafish larvae.