Salmonella multimutants enable efficient identification of SPI-2 effector protein function in gut inflammation and systemic colonization
Joshua P. M. Newson, Flavia Gürtler, Pietro Piffaretti, Nicolò Barbieri, A Meyer, Anna Sintsova, Manja Barthel, Yves Steiger, Sarah C. McHugh, Ursina Enz, Neal M. Alto, Shinichi Sunagawa, Wolf‐Dietrich Hardt
The paper uses multimutant Salmonella strains to identify SPI-2 effector functions in gut inflammation and systemic colonization, finding SopD2 and GtgE critical for mucosal pathology.
Nature Communications · Nov 6, 2025Peer-reviewedMicrobiology