Author

Joshua P. M. Newson

ETH ZurichORCID 0000-0003-2091-7943Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Approach:statistical model· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Wolf‐Dietrich HardtiD· 2 shared A MeyeriD· 1 shared Anna SintsovaiD· 1 shared Chase L. BeiseliD· 1 shared Flavia GürtleriD· 1 shared Manja BartheliD· 1 shared Neal M. AltoiD· 1 shared Nicolò Barbieri· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersMicrobiology

Wolf‐Dietrich HardtORCID

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2 papers

Recent·Most cited

MicrobiologybioRxivPreprintFeb 12, 2026

Dissecting multi-gene virulence phenotypes with base editing requires consideration of target-independent mutagenesis

Joshua P. M. Newson, Sandra Gawlitt, Sneha Sundar…·Wolf‐Dietrich Hardt

The paper develops a base-editing pipeline for multi-gene knockouts in Salmonella Typhimurium, showing reduced virulence but also off-target mutations affecting fitness.

DOI 10.64898/2026.02.11.705302

bacteria (other)whole-genome sequencing

𝕏 PostBluesky

MicrobiologyNature CommunicationsPeer-reviewedNov 6, 2025

Salmonella multimutants enable efficient identification of SPI-2 effector protein function in gut inflammation and systemic colonization

Joshua P. M. Newson, Flavia Gürtler, Pietro Piffaretti…·Wolf‐Dietrich Hardt

The paper uses multimutant Salmonella strains to identify SPI-2 effector functions in gut inflammation and systemic colonization, finding SopD2 and GtgE critical for mucosal pathology.

6 citations

mouseexperimental assay

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