Nicole A. Lynch

Fentanyl + Xylazine Co Administration Leads to Sustained Depression of Breathing and Body Temperature Likely Driven by mu Opioid and alpha2a Adrenergic Pathway Interactions

This paper investigates the combined effects of fentanyl and xylazine on respiratory and thermoregulatory function in mice, finding that their co-administration leads to prolonged respiratory depression and hypothermia through interactions between mu opioid and alpha2a adrenergic pathways.

Melanocortin-responsive Kiss1 neurons of the arcuate nucleus drive energy expenditure through glutamatergic signaling to the dorsomedial hypothalamus.

The paper identifies arcuate nucleus Kiss1 neurons as regulators of energy expenditure through glutamatergic signaling to the dorsomedial hypothalamus in male mice.

Identifying the Brain Circuits that Regulate Pain-Induced Sleep Disturbances

The paper identifies parabrachial CGRP neurons as regulators of awakenings to pain and shows their role in pain-induced sleep disturbances.