Natalia Machado

This study identifies a hypothalamic pathway involving ARCAgRP neurons and the MnPO that triggers energy conservation during fasting.

This paper investigates the combined effects of fentanyl and xylazine on respiratory and thermoregulatory function in mice, finding that their co-administration leads to prolonged respiratory depression and hypothermia through interactions between mu opioid and alpha2a adrenergic pathways.

The paper identifies arcuate nucleus Kiss1 neurons as regulators of energy expenditure through glutamatergic signaling to the dorsomedial hypothalamus in male mice.

The paper identifies IRF3 as a key transcriptional regulator of leptin's hunger-suppressing effects in AgRP neurons through integrated genomic analysis.