Monocyte-endothelial interactions as a targetable node in clonal hematopoiesis-mediated cardiovascular disease
Alyssa Parker, Jonathan Brett Heimlich, Joseph C. Van Amburg, Yash Pershad, David E. Ong, Nicole A. Mickels, Laventa M. Obare, Ketan J Hoey, Hannah K. Giannini, Ayesha Karim Ahmad, Caitlyn Vlasschaert, Tarak Nandi, Ravi Madduri, Samuel S. Bailin, John Robert Koethe, , Alexander G. Bick
The paper identifies monocyte-endothelial interaction alterations in TET2 CHIP and shows that targeting CXCR2 and ICAM1 can restore normal interactions.
medRxiv · Feb 20, 2024 · PreprintGenetic & Genomic Medicine