Alyssa Parker

The paper identifies mutation-specific impairments in TET2 and DNMT3A enzymatic activity as predictors of clonal hematopoiesis disease risk using methylation-based activity scores.

The paper introduces a closed-loop framework for single-cell foundation models that incorporates perturbation data to improve prediction accuracy, identifying therapeutic targets and pathways in RUNX1-familial platelet disorder.

This study profiles single-cell multiomic data from clonal hematopoiesis patients and controls, revealing pro-inflammatory profiles in monocytes and T cell dysfunction.

The paper identifies monocyte-endothelial interaction alterations in TET2 CHIP and shows that targeting CXCR2 and ICAM1 can restore normal interactions.

The paper analyzes DNA methylation patterns in five pediatric tumor types, finding hypermethylation is more common than hypomethylation and identifying gene methylation patterns associated with patient subsets.