Celestine N. Wanjalla

Human Th17 state classification reveals a selective vulnerability in acylcarnitine metabolism in type 2 diabetes

The paper classifies human Th17 cells into non-pathogenic and pathogenic states and identifies acylcarnitine metabolism as a vulnerability in type 2 diabetes.

ATF4 Coordinates Transcriptomic and Structural Adaptations in Aging Muscle

This study shows ATF4 coordinates transcriptomic and structural changes in aging muscle, linking it to mitochondrial dysfunction and suggesting the ISR pathway as a therapeutic target.

Characterization of Distinct Monocyte Subtypes and Immune Features Associated with HIV, Tuberculosis, and Coronary Artery Disease in a Ugandan Cohort Using Mass Cytometry

The paper uses mass cytometry to analyze monocyte subtypes in a Ugandan cohort with HIV, TB, and CAD, identifying distinct phenotypes linked to disease states.

Brush border intermicrovillar adhesion limits bacterial attachment to the small intestine brush border

The paper shows that intermicrovillar adhesion complexes limit bacterial attachment to the small intestine brush border, with SFB remodeling actin to anchor to epithelial junctions.

Myeloid Cell Glucocorticoid, Not Mineralocorticoid Receptor Signaling, Contributes to Salt-Sensitive Hypertension in Humans via Cortisol

This study identifies glucocorticoid receptor (GR) signaling in myeloid cells as a key contributor to salt-sensitive hypertension (SSBP) through SGK1 and IsoLG pathways, distinct from mineralocorticoid receptor (MR) mechanisms.

Monocyte-endothelial interactions as a targetable node in clonal hematopoiesis-mediated cardiovascular disease

The paper identifies monocyte-endothelial interaction alterations in TET2 CHIP and shows that targeting CXCR2 and ICAM1 can restore normal interactions.