Cryptococcus neoformans rewires the conserved Wee1-CDK checkpoint through two divergent kinases required for replication-stress tolerance and virulence
Jin-Tae Choi, Rodney J. Colón-Reyes, Dong‐Hoon Yang, Seung‐Heon Lee, Setareh Etesham, Nicole Bodner, Ki Tae Suk, Srikripa Chandrasekaran, Lukasz Kozubowski, Yong‐Sun Bahn
This study identifies two divergent Wee1-family kinases in Cryptococcus neoformans that function in a dosage-sensitive checkpoint to promote stress adaptation and virulence.
bioRxiv · Jun 25, 2026 · PreprintMicrobiology