Author

Nicole Castagna

Johns Hopkins University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Ajay M. VaghasiaiD· 2 shared Alok Mishra· 2 shared Angelo Michael De MarzoiD· 2 shared Jasmine Yun-Tong KungiD· 2 shared Jordan M. GreggiD· 2 shared Rulin WangiD· 2 shared Srinivasan YegnasubramanianiD· 2 shared William G. NelsoniD· 2 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCell Biology

Ajay M. VaghasiaORCID

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2 papers

Recent·Most cited

A transition zone enriched WIF1⁺ basal cell subtype is associated with benign prostatic hyperplasia

Rulin Wang, Qizhi Zheng, Mindy Kim Graham, Ajay M. Vaghasia, Jianyong Liu, Jordan M. Gregg, Tracy Jones, Anuj Gupta, Nicole Castagna, Yan Zhang, Kornel Schuebel, Jennifer L. Meyers, Alyza Skaist, Dixie L. Hoyle, Jasmine Yun-Tong Kung, , Srinivasan Yegnasubramanian

The paper identifies a WIF1+ basal cell subtype enriched in the transition zone of the prostate and links it to benign prostatic hyperplasia through molecular and pathway analyses.

The Journal of Pathology · Sep 10, 2026Peer-reviewedCell Biology

Triptolide sensitizes cancer cells to nucleoside DNA methyltransferase inhibitors through inhibition of DCTPP1-mediated cell-intrinsic resistance

Jianyong Liu, Qing-Li He, Jianya Zhou, Ajay M. Vaghasia, Roshan V. Chikarmane, Glenn Hauk, Archana Rachakonda, Nicole Castagna, Ruchama Chaya Steinberg, Minh‐Tam Pham, Jordan M. Gregg, Alok Mishra, Yuhan Yang, Talha Anwar, Roy Elias, , Srinivasan Yegnasubramanian

This paper identifies triptolide as a compound that enhances the effectiveness of DNMTi by inhibiting DCTPP1, overcoming resistance in cancer cells.

Nature Communications · Aug 26, 2026Peer-reviewedCancer Biology