Tartrate-resistant acid phosphatase (TRAP/ACP5) sex-specifically regulates bone maintenance in old mice, but the anabolic effects of mechanical loading is regulated in a sex-independent way
Bhavik Rathod, Hasmik Jasmine Samvelyan, Nicole Gustafsson, Aneta Liszka, Narelle E. McGregor, Jianyao Wu, Claes Ohlsson, Anna Fahlgren, Natalie A. Sims, Jonas Fuxe, Göran N. Andersson, Jessica J. Alm, Sara H. Windahl
This study shows TRAP regulates sex-specific bone maintenance and mechanical loading responses in old mice, with TRAP-deficiency impairing bone formation in both sexes.
bioRxiv · Sep 3, 2025 · PreprintDevelopmental Biology