Optogenetic stimulation of Lbc GEF-mediated Rho activity dynamics promotes cell invasion
Jessica S. Wagner, Konstantina Feller, Nicole Schrenke, Nina Schulze, Annette Paschen, Leif Dehmelt, Perihan Nalbant
This study uses optogenetics to control Lbc GEF activity in melanoma cells, showing that increased Rho activity enhances contraction dynamics, spheroid expansion, and cell escape.
Molecular Biology of the Cell · Sep 17, 2025Peer-reviewedCell Biology