Nina Schulze

This study shows that constitutive plasma membrane association of active Ect2 suppresses pulsatile Rho activity dynamics during mitosis, unlike Lbc-type GEFs.

This paper compares the effects of USP7 inhibition and degradation in cancer cells, finding distinct phenotypic and proteomic responses.

This study shows that heparan sulfate (HS) is critical for integrin-mediated cell-matrix interactions and regulates glycosaminoglycan (GAG) synthesis through YAP signaling in chondrocytes.

This study uses optogenetics to control Lbc GEF activity in melanoma cells, showing that increased Rho activity enhances contraction dynamics, spheroid expansion, and cell escape.

This study shows ATXN3 helps restore lysosomal function after damage by targeting K48-K63-branched ubiquitin chains on regenerating lysosomes.

This study identifies HTRA1 as a non-autonomous protein quality control factor that inhibits tau aggregate propagation by interfering with multiple steps of the spreading process.