Perihan Nalbant

Constitutive plasma membrane interaction of active Rho GEF Ect2 inhibits cortex contraction pulses

This study shows that constitutive plasma membrane association of active Ect2 suppresses pulsatile Rho activity dynamics during mitosis, unlike Lbc-type GEFs.

Heparan sulfate-function is essential for Integrin-dependent cell-matrix interactions and regulates glycosaminoglycan synthesis synthesis through YAP

This study shows that heparan sulfate (HS) is critical for integrin-mediated cell-matrix interactions and regulates glycosaminoglycan (GAG) synthesis through YAP signaling in chondrocytes.

Logic-gating the HaloTag system with Conditional-Halo-ligator 'CHalo' reagents

The paper introduces CHalo reagents that conditionally ligate to HaloTag proteins, enabling light- or enzyme-triggered labeling, protein recruitment control, and enzyme activity recording.

Optogenetic stimulation of Lbc GEF-mediated Rho activity dynamics promotes cell invasion

This study uses optogenetics to control Lbc GEF activity in melanoma cells, showing that increased Rho activity enhances contraction dynamics, spheroid expansion, and cell escape.