HIV-1 promotes loss of CD4+ T cell stemness and enrichment of effector-like states via Vpr-mediated TCF7 degradation
Johanna Leyens, Anthea Darius, Carlos Alberto Vanegas-Torres, Brigitta Maurer, Ramona Businger, Nicole Woelfle, Praveen Baskaran, Stefanie M. Hauck, Michael Schindler
This study identifies Vpr-mediated TCF7 degradation as a mechanism by which HIV-1 reduces CD4+ T cell stemness and promotes effector-like states.
bioRxiv · Aug 4, 2026 · PreprintMicrobiology