Stefanie M. Hauck

This study identifies RTTN's role in ribosome biogenesis and tRNA modification in human brain organoids, showing mutations disrupt translation and cause cortical malformations.

This study identifies Vpr-mediated TCF7 degradation as a mechanism by which HIV-1 reduces CD4+ T cell stemness and promotes effector-like states.

This study identifies miR-940 as a negative regulator of ferroptosis, showing it suppresses cell death by modulating key genes and GPX4 levels in cancer cells.

The paper shows that Hmgb2 enhances astrocyte-to-neuron conversion by regulating chromatin accessibility of neuronal maturation genes in response to growth factors.

LEOPARD completes missing views in multi-timepoint omics data by disentangling content and temporal representations, outperforming existing methods on benchmark datasets.

This study shows that EVs deplete GGA2 in beta cells, causing Golgi acidification and altering the MHC class I immunopeptidome through premature cathepsin activation.

The paper identifies TGIF2 as a key regulator of neural stem cell fate and neurogenic priming through transcriptomic and chromatin analysis in mouse brain development.

This study identifies sex-specific molecular differences in human skeletal muscle and shows that endurance training reduces these differences.

The paper identifies SRRM2 as a surface-exposed cancer target and shows its utility in CAR-T cell therapy.

The paper benchmarks dia-PASEF with timsTOF HT for high-throughput proteome analysis in a multi-center study, showing consistent protein and peptide identification across laboratories.

The paper identifies the glucocorticoid receptor as a master regulator of Muller cell gliosis in diabetic retinopathy and shows that increasing GR expression can improve retinal function.

This study shows that PURA depletion affects posttranscriptional regulation and P-body formation, linking PURA Syndrome to neurodevelopmental disorders.

This study identifies cMet/HGFR as a modulator of early neuroinflammation in TBI, showing that its inhibition reduces microglial reactivity and improves recovery.

The paper presents a multi-omics cell line atlas for Ewing sarcoma, identifying new target genes and regulatory mechanisms of EWSR1-ETS fusion oncogenes.

The paper identifies VAMP5 as a SNARE component in extracellular vesicles released by retinal Muller glia and shows differences in their secretomes compared to neurons.

This study shows that transplanted neurons in traumatic brain injury environments form excessive but vulnerable connections, while fewer connections are formed in intact or inflamed brains.

This study identifies a synaptic mechanism linking collagen VI to motor control through cannabinoid receptor interaction and shows that CB1R agonists can improve motor performance in a dystonia mouse model.

This study identifies TSC22D4 as an Akt1-interacting protein regulated by metabolic and stress signals, revealing its role in cellular processes and metabolic homeostasis.

The paper identifies proteomic changes in a Dravet syndrome mouse model, showing altered pathways related to seizures and neurodevelopment.

This study identifies plasma proteins associated with the placebo effect in nausea using proteomics and shows they predict placebo response.

The paper identifies cell type-specific complement expression patterns in healthy and diseased retinas across human and murine models, highlighting age-related and disease-induced changes.