Author

Johanna Leyens

Universitätsklinikum TübingenORCID 0009-0009-1689-4751Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell-cell communication· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

Michael SchindleriD· 2 shared Anthea Darius· 1 shared Brigitta Maurer· 1 shared Carlos Alberto Vanegas-Torres· 1 shared Gabriela TurkiD· 1 shared Georgios Vavouras Syrigos· 1 shared Lea Marie Meckes· 1 shared Nicole Woelfle· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersMicrobiology

Michael SchindlerORCID

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2 papers

Recent·Most cited

MicrobiologybioRxivPreprintAug 4, 2026

HIV-1 promotes loss of CD4+ T cell stemness and enrichment of effector-like states via Vpr-mediated TCF7 degradation

Johanna Leyens, Anthea Darius, Carlos Alberto Vanegas-Torres…·Michael Schindler

This study identifies Vpr-mediated TCF7 degradation as a mechanism by which HIV-1 reduces CD4+ T cell stemness and promotes effector-like states.

DOI 10.64898/2026.07.31.741970

humanproteomics

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MicrobiologyJournal of VirologyPeer-reviewedMar 25, 2025

CD4+ T cells facilitate replication of primary HIV-1 strains in macrophages and formation of macrophage internal virus-containing compartments.

Sabina Victoria, Johanna Leyens, Lea Marie Meckes…·Michael Schindler

This study shows that non-infected CD4+ T cells enhance replication of primary HIV-1 in macrophages and promote formation of virus-containing compartments (VCCs).

7 citations

humanexperimental assay

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