TDP-43 regulates GAD1 mRNA splicing and GABA signaling in Drosophila brains
Giulia Romano, Nikola Holodkov, Raffaella Klima, Fabian M. Feiguin
This study shows that TDP-43 regulates GAD1 mRNA splicing and GABA signaling in Drosophila brains, and that modulating GABA neurotransmission can reverse locomotion defects in TDP-43-deficient flies.
Scientific Reports · Sep 21, 2021Peer-reviewedNeuroscience