Author

Fabian M. Feiguin

University of CagliariORCID 0000-0002-8486-7546Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:Drosophila· 3 Approach:experimental assay· 3 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Giulia RomanoiD· 3 shared Raffaella KlimaiD· 2 shared Aram MegighianiD· 1 shared Claudia PellacaniiD· 1 shared Clelia Introna· 1 shared Federico Riccardi· 1 shared Laura CiapponiiD· 1 shared Marta MarzulloiD· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersNeuroscience

Giulia RomanoORCID

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3 papers

Recent·Most cited

Su(var)3-9 mediates age-dependent increase in H3K9 methylation on TDP-43 promoter triggering neurodegeneration

Marta Marzullo, Giulia Romano, Claudia Pellacani, Federico Riccardi, Laura Ciapponi, Fabian M. Feiguin

The paper shows that Su(var)3-9 increases H3K9 methylation on the TDP-43 promoter with age, leading to reduced TDP-43 expression and neurodegeneration in Drosophila, mice, and humans.

Cell Death Discovery · Sep 27, 2023Peer-reviewedMolecular Biology

TDP-43 regulates GAD1 mRNA splicing and GABA signaling in Drosophila brains

Giulia Romano, Nikola Holodkov, Raffaella Klima, Fabian M. Feiguin

This study shows that TDP-43 regulates GAD1 mRNA splicing and GABA signaling in Drosophila brains, and that modulating GABA neurotransmission can reverse locomotion defects in TDP-43-deficient flies.

Scientific Reports · Sep 21, 2021Peer-reviewedNeuroscience

TDP-43 regulates the expression levels of Disc-large in skeletal muscles to promote the assemble of the neuromuscular synapses in Drosophila

Nina Strah, Giulia Romano, Clelia Introna, Raffaella Klima, Aram Megighian, Monica Nizzardo, Fabian M. Feiguin

This study shows TDP-43 promotes neuromuscular synapse formation in Drosophila by regulating Disc-large expression, with similar mechanisms observed in human ALS tissues.

bioRxiv · Jul 26, 2019 · PreprintNeuroscience