Lipid Nanoparticle Delivery of Mesenchymal Stromal Cell-Derived microRNA 187-3p as a First-in-Class Therapy for Myocardial Dysfunction in Sepsis
Amin M. Ektesabi, Maria Carolina Barbosa‐Silva, James N. Tsoporis, Samantha McWhirter, Chirag M. Vaswani, Yanis Mouloud, Logan W. C. Zettle, Abdalla Ahmed, Paul Delgado-Olguı́n, Sabrina Setembre Batah, Jean‐François Desjardins, Sahil Gupta, Greaton W. Tan, Jacqueline L. Pavelick, Yanbo Wang, , Claúdia C. dos Santos
This paper demonstrates that lipid nanoparticle-delivered miR-187 reduces inflammation and improves cardiac function in sepsis models.
bioRxiv · Sep 9, 2025 · PreprintMolecular Biology