Harnessing the Embryo Antitumor Factor NEPN for Broad-Spectrum Cancer Immunotherapy via Dual Modulation of Tumor Progression and Immune Suppression
Tzu‐Pei Chang, Yu-Jui Ho, Mohamad Hamieh, Xin Huang, Nina Kim, Rajasekhar Vinagolu, Cheng Zhang, Rui Zhao, Shannon Mckinney-Freeman, Hu Li, Scott W. Lowe, Michel Sadelain, Kitai Kim
This study identifies NEPN as a tumor-suppressive embryonic factor that enhances cancer immunotherapy by modulating TGFβ1 signaling and immune responses in both non-solid and solid tumors.
bioRxiv · Sep 29, 2025 · PreprintCancer Biology