Hu Li

This study identifies NEPN as a tumor-suppressive embryonic factor that enhances cancer immunotherapy by modulating TGFβ1 signaling and immune responses in both non-solid and solid tumors.

The paper identifies FNDC4 as a gene associated with alcohol use disorder through GWAS and shows its role in regulating neurogenesis via alternative splicing and CRISPR/Cas9 experiments.

The paper investigates how aging-dependent dysregulation of EXOSC2 affects cellular traits and finds that PPP2R5E, a PP2A phosphatase subunit, is a key target of EXOSC2, with this regulation maintained in stem cells and cancer.

The paper identifies KDM4 demethylase inhibition as a therapeutic strategy for lymphoma and other cancers by rewiring heterochromatin and inducing DNA damage.

The paper identifies invariant feature genes (IFGs) using a symmetric machine learning approach to distinguish healthy from disease states and finds drug targets in cancer IFGs.

This study shows TIA1 regulates divergent inflammatory responses in microglia and macrophages, reducing brain inflammation and tau pathology while increasing peripheral inflammation.

This study uses scRNA-seq to analyze the tumor microenvironment and cell types in ovarian clear cell carcinoma, identifying immune infiltration and similarities with endometriosis.

The paper shows glucocorticoid exposure reveals the function of non-coding genetic variants linked to disease risk by influencing gene expression in relevant biological processes.

The paper identifies DiSCs, regions co-bound by SETDB1 and Cohesin, which regulate genome topology and stem cell fate in mouse embryonic stem cells.

The paper identifies conjunctival cells as potential entry points for SARS-CoV-2 by showing they express both ACE2 and TMPRSS2 receptors.

The paper identifies SERPINA5 as a novel tau binding partner in Alzheimer's disease by analyzing hippocampal gene expression and neurofibrillary tangles.

This paper identifies a complex involving HNRNPA2B1, N6-methyladenosine modified transcripts, and toxic tau oligomers that mediates neurodegeneration.

The paper identifies essential enhancers for pluripotency in mouse ES cells using a CRISPR-Cas9 screen and characterizes their target genes and regulatory networks.

This study uses scRNA-Seq and scATAC-Seq to show that human reprogramming occurs through asynchronous, diverse trajectories with distinct regulatory networks.

The paper introduces ASTAR-Seq, a method for parallel single-cell transcriptome and chromatin accessibility sequencing, and uses it to analyze mESCs, human cell lines, and erythroblast differentiation.