Large-scale endoplasmic reticulum membrane solidification spatially organizes proteins under thermal or metabolic stress
Paul M. Mueller, Melissa R. Mikolaj, Elmehdi Belbaraka, Finn Hartstein, Sophia Altinoluk, Bjoern Perder, Philipp Trnka, Robert-William Welke, Heike Naumann, Nina Taudien, Séverine Kunz, Michele Solimena, Ilya Levental, Kandice R. Levental, Andreas Müller, , Oliver Rocks
The paper identifies a temperature- and lipid saturation-dependent transformation of ER membranes into rigid tubes under stress, driven by lipid demixing and protein segregation.
bioRxiv · Apr 12, 2026 · PreprintCell Biology