M102, a combined NRF2 and HSF-1 activator for neuroprotection in amyotrophic lateral sclerosis.
Amy F. Keerie, Raquel Rua Martins, Chloe F. Allen, Katie M Bowden, Sufana Al Mashhadi, Thomas R. Marlow, Monika A. Myszczynska, Nikitha Thakur, Selina N. Beal, Allan Christian Shaw, Shivani Suresh, Scott N. McKinnon, Alex Daniel, Tyler R. Wells, Ira N. Kalfus, , Richard J. Mead
M102, a dual NRF2/HSF1 activator, slows disease progression in 2 mouse models and exerts neuroprotection in human cellular models of ALS.
bioRxiv · Dec 8, 2024 · PreprintNeuroscience