Author
University of SheffieldORCID 0000-0003-3952-8649Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Raquel Rua Martins, Savandara Besse, Pam S. Ellis…·Catarina Martins Henriques
This study shows that telomerase deficiency in zebrafish accelerates brain ageing by promoting senescence, inflammation, and blood-brain barrier dysfunction.
Monika A. Myszczynska, Matthew J. Stopford, Nóra M. Márkus…·Laura Ferraiuolo
This paper uses AI to identify gefitinib as a potential ALS treatment, showing it protects motor neurons and reduces TDP-43 fragments in vitro and in vivo.
Amy F. Keerie, Raquel Rua Martins, Chloe F. Allen…·Richard J. Mead
M102, a dual NRF2/HSF1 activator, slows disease progression in 2 mouse models and exerts neuroprotection in human cellular models of ALS.
Lydia M. Castelli, Ya-Hui Lin, Álvaro Sánchez-Martínez…·Guillaume M. Hautbergue
This paper develops a cell-penetrant peptide that blocks C9ORF72-repeat RNA nuclear export, reducing neurodegeneration in preclinical models of ALS and FTD.
Raquel Rua Martins, Mazen E. Zamzam, Dhani Tracey‐White…·Ryan B. MacDonald
The paper shows that aged gliotic Müller glia in zebrafish retain regenerative potential and can be stimulated to repair damaged neurons despite age-related neurodegeneration.