Cryo-EM structural insights into Vγ9Vδ2 TCR activation via multiple butyrophilins
Mai Zhang, Yiqing Wang, Ningning Cai, Yingying Qu, Xianqiang Ma, Jing Xue, Xiaorui Chen, Xueguang Zhang, Junyu Xiao, Yonghui Zhang
This paper presents cryo-EM structures of BTN proteins interacting with phosphoantigens and the Vγ9Vδ2 TCR, revealing a 'pliers-like gripping' mechanism for TCR activation.
Immunity · Jun 11, 2025Peer-reviewedImmunology