Jing Xue

Cross-species analysis identifies APOBEC3-associated spliceosomal snRNA hypermutability

The paper identifies APOBEC3-associated hypermutability in spliceosomal snRNA genes across species, showing lineage-specific activity rather than R-loop formation alone.

TRIM21 licenses pancreatic acinar fate by modulating BiP phase state through VCP-dependent retrotranslocation

This study identifies TRIM21 as a regulator of BiP phase state under ER stress, preventing solidification and maintaining UPR function, with implications for pancreatic cancer.

Direct detection of meiotic recombination events in the highly heterozygous amphioxus genome

This paper develops a bioinformatic pipeline to detect meiotic recombination events in the highly heterozygous amphioxus genome using short-read sequencing of a two-generation pedigree.

NQO1 phase condensation promotes stress granule assembly to facilitate pancreatic carcinogenesis

This study identifies NQO1's role in promoting stress granule assembly via phase separation to drive pancreatic carcinogenesis, independent of ROS.

Cryo-EM structural insights into Vγ9Vδ2 TCR activation via multiple butyrophilins

This paper presents cryo-EM structures of BTN proteins interacting with phosphoantigens and the Vγ9Vδ2 TCR, revealing a 'pliers-like gripping' mechanism for TCR activation.

IRAK2 deficiency causes a new immune dysregulation disorder

IRAK2 deficiency causes immune dysregulation by disrupting TLR signaling and activating type I interferon responses in monocyte-macrophage lineage.