Junyu Xiao

This study determines cryo-EM structures of FcR bound to IgM and IgA, revealing its binding mechanism and evolutionary insights into pIg receptor recognition.

The paper presents cryo-EM structures of complement convertases and their complexes to elucidate the molecular mechanisms of C3 recognition and activation in the classical and alternative pathways.

The paper presents the cryo-EM structure of Xenopus IgX, revealing a hexameric assembly that informs strategies for engineering human IgM and IgG hexamers with therapeutic applications.

This paper presents cryo-EM structures of BTN proteins interacting with phosphoantigens and the Vγ9Vδ2 TCR, revealing a 'pliers-like gripping' mechanism for TCR activation.

This study identifies ultra-potent Omicron-specific antibodies targeting the N1/N2 loop of the Spike NTD, which neutralize SARS-CoV-2 by competing with ACE2 and blocking S1 shedding, but are evaded by BA.2.86 and BA.2.87.1 sublineages.

The paper reports the cryo-EM structure of a potent SARS-CoV-2 NAb, BD-368-2, showing it blocks ACE2 binding and induces structural changes in the spike trimer, distinct from other NAbs.