FoTO1 is an epoxide isomerase in paclitaxel biosynthesis
Jie Bai, Jing Li, Yi Zhang, Hong Chang, Ningwei Zhang, Yuwan Liu, Jian Cheng, Xiaonan Liu, Huifeng Jiang
This study identifies FoTO1 as an epoxide isomerase that facilitates the productive rearrangement of taxadiene-4(5)-epoxide in paclitaxel biosynthesis.
bioRxiv · Apr 1, 2026 · PreprintBiochemistry