Structure-based design of soluble prefusion-stabilized herpes simplex virus type 2 glycoprotein B antigens
Madeline R. Sponholtz, Daphne Ma, Emmanuel Ndashimye, Patrick O. Byrne, Yi Shu, Christopher Warren, Nithya Thambi, Ryan S. McCool, Matthew D. Slein, Nicole V. Johnson, William A. Rose, Lan Zhang, Eberhard Dürr, Dai Wang, Jason S. McLellan
This study designs prefusion-stabilized HSV-2 gB antigens using structure-based methods and evaluates their immunogenicity, finding no improvement in neutralizing antibody titers compared to postfusion constructs.
Cell Reports · Sep 1, 2026Peer-reviewedMicrobiology