Nicole V. Johnson

This study isolates and characterizes monoclonal antibodies against Toscana virus's Gc glycoprotein, identifying cross-reactive antibodies that protect against Rift Valley Fever Virus.

This study designs prefusion-stabilized HSV-2 gB antigens using structure-based methods and evaluates their immunogenicity, finding no improvement in neutralizing antibody titers compared to postfusion constructs.

The paper identifies antibodies that block PlGF or VEGFA interactions with NRP1, showing anti-proliferative effects in cancer cells and reduced angiogenesis.

The paper identifies prefusion-specific human antibodies against HSV-2 gB that neutralize both HSV-1 and HSV-2 and protect neonatal mice.

This study characterizes the DRT1 antiphage defence system, showing it generates semirandom DNA adducts that regulate filament assembly and function through structural changes.

This paper introduces MAGE, a model that generates paired human antibody sequences against specific targets, validated against SARS-CoV-2, H5N1, and RSV-A.

The paper identifies a pan-betacoronavirus antibody that binds the S2 subunit of spike proteins and induces Fc-dependent antiviral responses, offering insights into non-neutralizing antibody protection.

This paper describes the stabilization of HCMV gB in a prefusion-like conformation using structure-based design and shows similar neutralizing antibody titers against postfusion and prefusion forms.

The paper profiles cleavage specificity and kinetics of CRISPR nucleases using NucleaSeq and CHAMP, finding engineered Cas9s show improved specificity while wtCas12a has similar specificity to wtCas9 in vitro.