Author

Ryan S. McCool

The University of Texas at AustinORCID 0000-0001-8833-8847Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Microbiology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Research Focus:protein structure prediction· 2 Assay:cryo-EM· 1 Approach:deep learning· 1 Research Focus:protein design· 1 Assay:protein structure· 1 Assay:structural biology· 1

Frequent Co-Authors

Jason S. McLellaniD· 3 shared Madeline R. SponholtziD· 3 shared Patrick O. ByrneiD· 3 shared Nicole V. JohnsoniD· 2 shared Abigail E. PowelliD· 1 shared Adelaide S. FulleriD· 1 shared Ajit R. RamamohaniD· 1 shared Alison G. LeeiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersMicrobiology

Jason S. McLellanORCID

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3 papers

Recent·Most cited

MicrobiologyCell ReportsPeer-reviewedSep 1, 2026

Structure-based design of soluble prefusion-stabilized herpes simplex virus type 2 glycoprotein B antigens

Madeline R. Sponholtz, Daphne Ma, Emmanuel Ndashimye…·Jason S. McLellan

This study designs prefusion-stabilized HSV-2 gB antigens using structure-based methods and evaluates their immunogenicity, finding no improvement in neutralizing antibody titers compared to postfusion constructs.

1 citation

humancryo-EM

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BiochemistrybioRxivPreprintMay 19, 2025

Design, Structure, and Immunogenicity of a Soluble Prefusion-stabilized EBV gB Antigen

Ryan S. McCool, Cory M. Acreman, Abigail E. Powell…·Jason S. McLellan

This study designs and characterizes a prefusion-stabilized EBV gB antigen, showing improved immunogenicity and structural insights for vaccine development.

2 citations

humanstructural biology

𝕏 PostBluesky

Molecular BiologyProceedings of the National Academy of SciencesPeer-reviewedSep 4, 2024

Structure-based design of a soluble human cytomegalovirus glycoprotein B antigen stabilized in a prefusion-like conformation

Madeline R. Sponholtz, Patrick O. Byrne, Alison G. Lee…·Jason S. McLellan

This paper describes the stabilization of HCMV gB in a prefusion-like conformation using structure-based design and shows similar neutralizing antibody titers against postfusion and prefusion forms.

37 citationstop 1%

humanprotein structure

𝕏 PostBluesky