Gene transcription and chromatin packing domains form a self-organizing system
Lucas M. Carter, Wing Shun Li, Ruyi Gong, Nicolas Acosta, niyati pandya, Marcelo A. Carignano, Emily M. Pujadas-Liwag, kunlun wang, Tiffany Kuo, Kyle L. MacQuarrie, Masato T. Kanemaki, Luay Matthew Almassalha, Vadim Backman
The paper shows that Pol-II regulates chromatin packing domains through transcriptional loops, linking RNA synthesis to genome organization and gene expression.
bioRxiv · Mar 17, 2026 · PreprintMolecular Biology