Nicolas Acosta

This study shows that HP1 stabilizes chromatin packing domains by maintaining their structure and enabling efficient transcriptional responses to stress.

This study shows that chromatin architecture and physical constriction together drive phenotype switching and metastasis in melanoma by altering CTCF positioning and heterochromatin structure.

The paper shows that Pol-II regulates chromatin packing domains through transcriptional loops, linking RNA synthesis to genome organization and gene expression.

This paper develops a three-color single-molecule localization microscopy protocol to study chromatin structure, revealing that heterochromatin and euchromatin are not distinct territories but are spatially coupled.

The paper investigates how nuclear blebs alter chromatin packing domains, finding fragmentation of nanoscopic heterochromatin domains within blebs.

This paper introduces csPWS-seg, a deep learning model for automated nuclei segmentation in label-free live cell csPWS microscopy, achieving high accuracy with median IoU 0.80 and DSC 0.88.

The paper shows that RNA polymerase I co-regulates chromatin domains and mRNA synthesis with RNA polymerase II, affecting genome connectivity and gene expression.

This study shows that formamide in 3D FISH distorts nanoscale chromatin structure, while alternative methods like RASER-FISH and CRISPR-Sirius have minimal impact.