ACTIVATION OF THE ARYL HYDROCARBON RECEPTOR REDUCES VISCERAL HYPERSENSITIVITY IN A MOUSE MODEL OF COLITIS IN REMISSION
Yasaman Bahojb Habibyan, Colin Mackenzie, Armaan Mohan, Cristiane H Baggio, Noah Gordon, Md Abu Naser Mohon, TIM SHUTT, Manon Defaye, Christina Thornton, Braedon McDonald, Christophe Altier, Keith A Sharkey, Yasmin Nasser
This study shows that activating the AhR in TRPV1+ nociceptors reduces visceral hypersensitivity in post-colitis mice, suggesting AhR as a therapeutic target for IBD-related abdominal pain.
bioRxiv · Nov 5, 2026 · PreprintNeuroscience