Keith A. Sharkey

This study shows that activating the AhR in TRPV1+ nociceptors reduces visceral hypersensitivity in post-colitis mice, suggesting AhR as a therapeutic target for IBD-related abdominal pain.

This study shows that intestinal macrophages have region-specific trophic requirements and neuroimmune functions, with CSF1 playing a key role in small-intestinal nitrergic neuron-macrophage interactions.

This study identifies C1qa⁺ muscularis macrophages as regulators of enteric synaptic homeostasis and gastrointestinal motility through complement-dependent mechanisms.

This study shows that early-life gut microbiome and stress-axis disruptions impair immune and neurodevelopmental health by altering microbial diversity, SCFA production, and neuroimmune responses.

This study shows T cells regulate intestinal motility and enteric neuronal responses to microbiota, with distinct roles in ileum and colon.

This study shows that the gut microbiota influences sexual dimorphism in ALS-linked TDP43 mice by affecting disease onset and severity, independent of sex hormones.