Author

Braedon McDonald

University of CalgaryORCID 0000-0001-8936-8992Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Alexandra TroitskayaiD· 1 shared Alexandria BartlettiD· 1 shared Alison Fox‐RobichaudiD· 1 shared Aminmohamed Manji· 1 shared Armaan MohaniD· 1 shared Asher A. Mendelson· 1 shared Ayesha WijesingheiD· 1 shared Breenna DobsoniD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperPathology

Alexandra TroitskayaORCID

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Author profile →

3 papers

Recent·Most cited

ACTIVATION OF THE ARYL HYDROCARBON RECEPTOR REDUCES VISCERAL HYPERSENSITIVITY IN A MOUSE MODEL OF COLITIS IN REMISSION

Yasaman Bahojb Habibyan, Colin Mackenzie, Armaan Mohan, Cristiane H Baggio, Noah Gordon, Md Abu Naser Mohon, TIM SHUTT, Manon Defaye, Christina Thornton, Braedon McDonald, Christophe Altier, Keith A Sharkey, Yasmin Nasser

This study shows that activating the AhR in TRPV1+ nociceptors reduces visceral hypersensitivity in post-colitis mice, suggesting AhR as a therapeutic target for IBD-related abdominal pain.

bioRxiv · Nov 5, 2026 · PreprintNeuroscience

Differential disease tolerance mediates sex-biased illness severity in sepsis

Breenna Dobson, Kathryn Strayer, Ayesha Wijesinghe, Jared Schlechte, Oscar Tejada, Alexandria Bartlett, Matthew Stephens, Diana Changirwa, Nicole A. Cho, Ian-Ling Yu, Nargis Khan, B McDonald

This study shows that male-biased sepsis severity is due to impaired disease tolerance, which can be improved by mitochondrial-targeted therapy.

Proceedings of the National Academy of Sciences · Feb 24, 2026Peer-reviewedPathology

Early sex-specific organ transcriptional divergence without physiological differences in a murine model of fecal-induced peritonitis

Alexandra Troitskaya, Aminmohamed Manji, Onon Batnyam, Eric K. Patterson, Forough Jahandideh, Dhruva J. Dwivedi, Manoj Mathew Lalu, Asher A. Mendelson, Braedon McDonald, Stephane L. Bourque, Kimberly F. Macala, Alison Fox‐Robichaud, Patricia C. Liaw, Gediminas Cepinskas, Ruud A. W. Veldhuizen, Sean E. Gill

This study examines early septic responses in male and female mice, finding sex-specific transcriptional differences in organs without physiological differences.

bioRxiv · Feb 19, 2026 · PreprintPathology